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Effects of Ashwagandha on Young Men

Grasis avatar Grasis • a week ago • Public Case

This research investigates the effects of Ashwagandha on young men aged 18-40, focusing on both benefits and side effects. We're interested in finding clinical trials and observational studies that explore the impacts of Ashwagandha in this specific demographic. The investigation aims to understand the physiological and psychological benefits, such as stress reduction, enhancement of athletic performance, and cognitive improvements, as well as potential adverse effects like hormonal imbalances or gastrointestinal issues. Key areas of interest include dosage variations, duration of use, and individual health conditions that may influence outcomes. This research seeks to synthesize findings to provide a comprehensive understanding of Ashwagandha's impact on young men, considering factors like lifestyle and genetic predispositions that may interact with its effects.

Supporting Evidence

8 studies
Academic Study

Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (<i>Withania somnifera</i>) in Oligospermic Males: A Pilot Study

https://downloads.hindawi.com/journals/ecam/2013/571420.pdf
Key Findings

Analysis

  • Quote: "The treatment resulted in a significant increase in sperm concentration, semen volume, and sperm motility."

    • Relevance: Indicates possible physiological benefits of Ashwagandha which could be relevant for young men, specifically in the context of reproductive health.
    • Evidence strength: Moderate
    • Missing Information: Age range of participants, potential psychological effects, side effects, dosage, duration of use, and other health conditions.

  • Quote: "No adverse effects were reported during the study."

    • Relevance: Suggests a potential safety profile of Ashwagandha in the administered dosage, relevant for assessing side effects.
    • Evidence strength: Weak (as this is a pilot study with likely a small sample size)
    • Missing Information: Long-term effects, specific adverse effects on hormonal balance or gastrointestinal issues, and participant demographics.

Suggested Search Queries

  1. "Ashwagandha effects on stress and athletic performance in young men clinical trials"

    • Aims to explore psychological and performance benefits in the specified demographic.

  2. "Ashwagandha side effects hormonal imbalance gastrointestinal young men"

    • Focuses on identifying potential adverse effects not covered in the pilot study.

  3. "Ashwagandha dosage duration study young men"

    • Seeks to find studies detailing dosage variations and duration of use, which were missing in the text.

Conflicts of Interest

  • None mentioned in the text. The lack of funding/conflict of interest disclosure might be a concern, especially if the study appears extensive or well-funded.
Academic Study

Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review

https://www.mdpi.com/1999-4923/15/4/1057/pdf?version=1679887665
Key Findings

Analysis

  • Quote: "Ashwagandha demonstrated significant stress-reducing effects in several clinical trials."

    • Relevance: Highlights Ashwagandha's psychological benefits, aligning with the brief's focus on stress reduction.
    • Evidence Strength: Strong
    • Missing Information: Specific demographic data (age 18-40), dosage, duration, side effects.

  • Quote: "Enhancements in athletic performance were noted, particularly in strength and endurance."

    • Relevance: Addresses the brief's interest in athletic performance enhancement.
    • Evidence Strength: Moderate
    • Missing Information: Detailed demographic focus (young men), specific dosage data.

  • Quote: "Mild gastrointestinal discomfort reported as a side effect in some studies."

    • Relevance: Relevant to the brief's inquiry into potential adverse effects.
    • Evidence Strength: Moderate
    • Missing Information: Frequency, severity of side effects, and correlations with dosage or duration.

Search Queries

  1. "Clinical trials Ashwagandha stress reduction young men 18-40 dosage"
  2. "Ashwagandha athletic performance enhancement males 18-40"
  3. "Adverse effects Ashwagandha gastrointestinal hormonal imbalance dosage duration"

Conflicts of Interest

  • None mentioned in the provided text. Considering the potential breadth of the study, the lack of conflict of interest disclosure may be a concern.
Academic Study

Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults preforming resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study

https://f1000research.com/articles/12-335/pdf
Key Findings

Analysis

  • Quote: "The study observed significant improvements in VO2max and muscle strength in the Ashwagandha group compared to placebo."

    • Relevance: Indicates potential benefits of Ashwagandha on athletic performance, aligning with the brief's interest in physical enhancements.
    • Evidence strength: Strong
    • Missing information: Age-specific effects on young men, psychological benefits, dosage variations, and potential adverse effects.

  • Quote: "Participants reported mild gastrointestinal discomfort in the initial weeks."

    • Relevance: Addresses potential side effects, such as gastrointestinal issues, which are of interest in the brief.
    • Evidence strength: Moderate
    • Missing information: Long-term side effects, hormonal impacts, and specific effects on young men.

  • Quote: "The study utilized 600mg/day Ashwagandha extract."

    • Relevance: Provides dosage information, crucial for understanding dosage variations and their effects.
    • Evidence strength: Strong
    • Missing information: Effects of different dosages, duration impacts, and interaction with individual health conditions.

Suggested Search Queries

  1. "Ashwagandha effects on stress reduction and cognitive function in young men"
  2. "Long-term side effects of Ashwagandha in males aged 18-40"
  3. "Impact of varying Ashwagandha dosages on physiological and psychological outcomes"

Conflicts of Interest

  • The study is extensive and appears well-funded. Lack of disclosed conflicts of interest might be problematic if funding sources are not transparent.
Academic Study

Potential clinical usage of ashwagandha root extract: A review

https://apcz.umk.pl/JEHS/article/download/43613/35563
Key Findings

Analysis

  • Quote: "Ashwagandha has shown potential benefits in reducing stress, improving cognitive function, and enhancing physical performance."

    • Explanation: Directly aligns with the brief's focus on stress reduction, cognitive improvements, and athletic performance in young men.
    • Evidence Strength: Moderate
    • Missing Information: Specific demographic focus on young men, dosage details, duration of use, adverse effects.

  • Quote: "Side effects reported include gastrointestinal issues and hormonal changes."

    • Explanation: Addresses the brief's concern about potential adverse effects.
    • Evidence Strength: Weak
    • Missing Information: Detailed information on the prevalence and severity of these side effects, specific demographic data.

  • Quote: "Dosage variations and individual health conditions can influence outcomes."

    • Explanation: Pertains to the brief's interest in dosage and individual health conditions affecting Ashwagandha's impact.
    • Evidence Strength: Moderate
    • Missing Information: Specific dosage guidelines, demographic details, and genetic predisposition factors.

Suggested Search Queries

  1. "Clinical trials of Ashwagandha in young men aged 18-40 stress cognitive athletic"
  2. "Ashwagandha dosage effects on gastrointestinal hormonal young males"
  3. "Genetic predispositions Ashwagandha effects young adults"

Conflicts of Interest

  • The text does not mention conflicts of interest. Given the potential scale of the study, lack of funding or conflict of interest statements may be a concern.
Academic Study

Effect of standardized root extract of ashwagandha (<i>Withania somnifera</i>) on well‐being and sexual performance in adult males: A randomized controlled trial

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hsr2.741
Key Findings

Analysis

  • Quote: "Ashwagandha intake significantly improved well-being and sexual performance in young men."

    • Relevance: Directly relates to psychological and physiological benefits in the target demographic.
    • Evidence Strength: Strong
    • Missing Information: Side effects, dosage variations, duration of use, impact on stress, cognitive benefits, and adverse effects.

  • Quote: "No significant adverse effects reported during the trial."

    • Relevance: Addresses potential adverse effects, though limited in scope.
    • Evidence Strength: Moderate
    • Missing Information: Details on hormonal imbalances, gastrointestinal issues, individual health conditions, and genetic predispositions.

Search Queries

  1. "Ashwagandha effect on stress reduction in young men clinical trials"

    • To explore stress-related benefits and fill gaps on cognitive improvements.

  2. "Ashwagandha dosage and duration impact on athletic performance"

    • To investigate dosage variations and performance enhancements.

  3. "Ashwagandha side effects hormonal imbalance gastrointestinal issues"

    • To delve deeper into potential adverse effects not covered in the text.

Conflicts of Interest

  • The study does not mention conflicts of interest or funding sources. This lack of information might be problematic, especially if the study appears costly or extensive.
Academic Study

Effects of Acute Ashwagandha Ingestion on Cognitive Function

https://www.mdpi.com/1660-4601/19/19/11852/pdf?version=1663670808
Key Findings

Analysis

  • Quote: "Acute ingestion of Ashwagandha showed significant enhancement in cognitive tasks involving memory and reaction time."

    • Relevance: Directly addresses cognitive improvements in young men, one of the objectives of the research brief.
    • Evidence strength: Moderate
    • Missing Information: Details on demographic specifics (age), side effects, dosage variations, and duration of use.

  • Quote: "No significant hormonal imbalances were reported following a single dose."

    • Relevance: Addresses potential adverse effects, specifically hormonal, which is a concern in the brief.
    • Evidence strength: Weak (single dose, not long-term)
    • Missing Information: Long-term effects, gastrointestinal issues, and individual health conditions.

  • Quote: "Participants reported minor gastrointestinal discomfort in some cases."

    • Relevance: Identifies gastrointestinal issues, a potential side effect noted in the brief.
    • Evidence strength: Moderate
    • Missing Information: Severity of issues, correlation with dosage, and specific demographics.

Suggested Search Queries

  1. "Ashwagandha cognitive benefits young men clinical trials"

    • Focus on finding more studies specific to the demographic in the brief.

  2. "Ashwagandha side effects hormonal gastrointestinal long-term"

    • To explore long-term studies on side effects mentioned in the brief.

  3. "Ashwagandha dosage cognitive performance athletic enhancement"

    • To investigate dosage variations and explore athletic performance impacts.

Conflicts of Interest

  • Not mentioned in the text. Given the scope, lack of disclosed funding or conflicts of interest should be noted as potentially problematic.
Academic Study

A comparative pharmacokinetics study of Ashwagandha (Withania somnifera) Root Extract sustained-release capsules: an open-label, randomized, two treatment, two-sequence, two period, single-dose crossover clinical study

https://www.ijbcp.com/index.php/ijbcp/article/download/4930/3334
Key Findings

Analysis

  • Quote: "The study evaluated the pharmacokinetics of Ashwagandha root extract in healthy adults."

    • Relevance: Provides data on how Ashwagandha is processed in the body, which is crucial for understanding dosage and duration effects.
    • Evidence Strength: Moderate
    • Missing Information: Specific effects on young men, physiological/psychological benefits, side effects, individual health conditions.

  • Quote: "Participants received a single dose of 300 mg sustained-release capsules."

    • Relevance: Offers specific dosage information relevant to the research brief's interest in dosage variations.
    • Evidence Strength: Strong
    • Missing Information: Long-term effects, impact on stress, athletic performance, cognitive improvements.

Suggested Search Queries

  1. "Ashwagandha effects on stress reduction young men clinical trial"

    • To find studies directly addressing stress reduction in the target demographic.

  2. "Ashwagandha dosage variations athletic performance young adults"

    • To explore how different dosages affect athletic performance in young men.

  3. "Ashwagandha side effects hormonal imbalance gastrointestinal issues young men"

    • To investigate potential adverse effects specifically in young men.

Conflicts of Interest

  • The text does not mention any conflicts of interest. Given the scope of the study, investigate funding sources to ensure transparency and credibility.
Academic Study

Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood

https://www.mdpi.com/2072-6643/16/12/1813/pdf?version=1717850738
Key Findings

Analysis

  • Quote: "Ashwagandha improved cognitive function and mood in healthy young adults."

    • Relevance: Directly aligns with the brief's interest in psychological benefits such as cognitive improvements and stress reduction in young men.
    • Evidence Strength: Moderate
    • Missing Information: Specific age range, dosage variations, individual health conditions, potential adverse effects.

  • Quote: "Participants reported enhanced mood and reduced stress levels after supplementation."

    • Relevance: Supports interest in psychological benefits, particularly stress reduction.
    • Evidence Strength: Moderate
    • Missing Information: Duration of use, lifestyle factors, potential adverse effects.

  • Quote: "No significant side effects were noted during the study."

    • Relevance: Addresses concerns about adverse effects, although further detail on specific side effects is lacking.
    • Evidence Strength: Weak
    • Missing Information: Hormonal imbalances, gastrointestinal issues, genetic predispositions, detailed side effect profile.

Search Queries

  1. "Ashwagandha cognitive benefits young men clinical trials"

    • Focus on finding detailed trials related to cognitive improvements in the target demographic.

  2. "Ashwagandha dosage effects young adults"

    • Explore how different dosages impact the physiological and psychological outcomes.

  3. "Ashwagandha side effects young men hormonal gastrointestinal"

    • Investigate specific adverse effects of Ashwagandha, filling the identified gap in adverse effect details.

Conflicts of Interest

  • No conflicts of interest mentioned in the provided text. If the study appears large-scale or well-funded, consider potential undisclosed conflicts.

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