Orphenadrine prevents 3ānitropropionic acidāinduced neurotoxicity <i>in vitro</i> and <i>in vivo</i>
Analysis
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Quote: "Orphenadrine prevents 3ānitropropionic acidāinduced neurotoxicity in vitro and in vivo."
- Relevance: Highlights a potential protective measure against neurotoxicity caused by 3-NPA, aligning with the brief's interest in protective strategies.
- Evidence strength: Moderate
- Missing Information: Details on specific toxic effects, mechanisms of action, dose-response relationships, systemic toxicity, and biomarkers.
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Quote: "Inhibition of mitochondrial complex II by 3-NPA leads to neurotoxicity."
- Relevance: Describes a mechanism of action for 3-NPA, relevant to understanding its toxicological profile.
- Evidence strength: Strong
- Missing Information: Dose-response data, impact on non-neurological systems, and long-term exposure effects.
Suggested Search Queries
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"3-NPA neurotoxic effects mechanism of action"
- To gain deeper insights into the mechanisms of 3-NPA-induced neurotoxicity.
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"3-NPA dose-response human studies"
- To identify studies that focus on the dose-response relationship of 3-NPA in humans.
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"Protective agents against 3-NPA toxicity"
- To explore other potential protective measures and strategies against 3-NPA toxicity.
Conflicts of Interest
- No conflicts of interest mentioned. Given the potentially large scope of the study, the absence of funding disclosures might be a concern.