Covid Vaccines and Activation of RAS and K-Ras Pathways

This research investigates the potential activation of both the intracellular Renin-Angiotensin System (RAS) and the K-Ras pathway through ACE2 binding by Covid-19 vaccines, specifically AstraZeneca, Pfizer, and Moderna. The study focuses on identifying evidence of activation at the cellular level, incorporating both in vitro and in vivo analyses. It aims to delineate the molecular interactions between vaccine-induced spike proteins and ACE2 receptors, with an emphasis on the extent of RAS and K-Ras pathway involvement. Key areas of interest include the biochemical signaling processes, such as phosphorylation events and downstream signaling cascades, particularly the engagement of the K-Ras oncogene. The research seeks to understand the potential activation mechanisms involving GTPase activity, MAP kinase pathways, and other intracellular mediators. While the clinical impact is of secondary interest, this study aims to provide a comprehensive mapping of cellular activation induced by Covid-19 vaccines. Variations across different cell types and experimental conditions are considered to offer a thorough perspective on the engagement of these pathways by the vaccines.